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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACHE
All Species:
42.73
Human Site:
Y459
Identified Species:
72.31
UniProt:
P22303
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22303
NP_000656.1
614
67796
Y459
Q
G
A
R
V
Y
A
Y
V
F
E
H
R
A
S
Chimpanzee
Pan troglodytes
XP_516857
643
72946
Y488
W
G
N
N
A
F
F
Y
Y
F
E
H
R
S
S
Rhesus Macaque
Macaca mulatta
NP_001121560
614
67754
Y459
Q
G
A
R
V
Y
A
Y
V
F
E
H
R
A
S
Dog
Lupus familis
XP_546946
611
67308
Y456
Q
G
A
R
V
Y
A
Y
I
F
E
H
R
S
S
Cat
Felis silvestris
Mouse
Mus musculus
P21836
614
68150
Y459
Q
G
A
R
V
Y
A
Y
I
F
E
H
R
A
S
Rat
Rattus norvegicus
P37136
614
68178
Y459
Q
G
A
R
V
Y
A
Y
I
F
E
H
R
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505841
602
68511
Y447
F
G
N
N
V
F
F
Y
Y
F
D
H
R
S
S
Chicken
Gallus gallus
P36196
767
83002
Y614
R
G
G
K
V
Y
A
Y
L
F
D
H
R
S
S
Frog
Xenopus laevis
NP_001121332
600
68177
Y445
T
G
N
R
V
Y
T
Y
Y
F
D
H
R
A
S
Zebra Danio
Brachydanio rerio
Q9DDE3
634
71980
Y476
S
H
G
A
V
Y
L
Y
L
F
D
H
R
A
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07140
649
71767
Y499
R
G
A
S
V
H
Y
Y
Y
F
T
H
R
T
S
Honey Bee
Apis mellifera
XP_393751
657
73886
Y485
T
G
N
T
V
Y
M
Y
Y
Y
K
H
R
S
M
Nematode Worm
Caenorhab. elegans
P38433
620
71415
Y449
H
G
G
D
T
Y
Y
Y
Y
F
T
H
R
A
S
Sea Urchin
Strong. purpuratus
XP_782113
508
56946
S371
V
P
G
F
D
K
D
S
E
S
L
L
N
R
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
99.5
92.8
N.A.
88.4
88.5
N.A.
50.6
47.9
59.6
60
N.A.
34.3
39.8
41.2
37.7
Protein Similarity:
100
66.8
99.6
96
N.A.
93
93.6
N.A.
68.2
58
73.4
73.6
N.A.
51.4
56.9
56.9
51.6
P-Site Identity:
100
46.6
100
86.6
N.A.
93.3
93.3
N.A.
46.6
60
66.6
53.3
N.A.
53.3
40
53.3
0
P-Site Similarity:
100
60
100
100
N.A.
100
100
N.A.
66.6
93.3
73.3
66.6
N.A.
66.6
60
53.3
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
43
8
8
0
43
0
0
0
0
0
0
50
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
8
0
8
0
0
0
29
0
0
0
8
% D
% Glu:
0
0
0
0
0
0
0
0
8
0
43
0
0
0
0
% E
% Phe:
8
0
0
8
0
15
15
0
0
86
0
0
0
0
0
% F
% Gly:
0
86
29
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
8
8
0
0
0
8
0
0
0
0
0
93
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
22
0
0
0
0
0
0
% I
% Lys:
0
0
0
8
0
8
0
0
0
0
8
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
8
0
15
0
8
8
0
0
0
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
29
15
0
0
0
0
0
0
0
0
8
0
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
36
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
15
0
0
43
0
0
0
0
0
0
0
0
93
8
0
% R
% Ser:
8
0
0
8
0
0
0
8
0
8
0
0
0
36
86
% S
% Thr:
15
0
0
8
8
0
8
0
0
0
15
0
0
8
0
% T
% Val:
8
0
0
0
79
0
0
0
15
0
0
0
0
0
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
72
15
93
43
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _